Login / Signup

Synthesis of Sulfonamide-Based Ynamides and Ynamines in Water.

Lei ZhaoHongyi YangRuikun LiYe TaoXiao-Feng GuoEdward A AndersonAndrew WhitingNa Wu
Published in: The Journal of organic chemistry (2020)
Ynamides, though relatively more stable than ynamines, are still moisture-sensitive and prone to hydration especially under acidic and heating conditions. Here we report an environmentally benign, robust protocol to synthesize sulfonamide-based ynamides and arylynamines via Sonogashira coupling reactions in water, using a readily available quaternary ammonium salt as the surfactant.
Keyphrases
  • ionic liquid
  • randomized controlled trial
  • room temperature