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Visible-Light Photoredox-Catalyzed Sulfonyl Lactonization of Alkenoic Acids with Sulfonyl Chlorides for Sulfonyl Lactone Synthesis.

Wei-Hao RaoQi LiFang-Yuan ChenLi-Li JiangPan XuXue-Wan DengMing LiGuo-Dong ZouXinhua Cao
Published in: The Journal of organic chemistry (2021)
A visible-light photoredox-catalyzed sulfonyl lactonization of unsaturated carboxylic acids with sulfonyl chlorides is described. This reaction features good functional group tolerance and a broad substrate scope, providing a simple and efficient protocol to access a wide range of sulfonyl lactones in high to excellent yields. Preliminary mechanistic investigations suggested that a free-radical pathway should be involved in the process.
Keyphrases
  • visible light
  • randomized controlled trial
  • room temperature