Alveolar macrophage transcriptomic profiling in COPD shows major lipid metabolism changes.

Wataru FujiiTheodore S KapellosKevin BaßlerKristian HändlerLisa HolstenRainer KnollStefanie Warnat-HerresthalMarie OestreichEmily R HinkleyJan HasenauerCarmen PizarroChristoph ThieleAnna C AschenbrennerThomas UlasDirk SkowaschJoachim L Schultze

Published in: ERJ open research (2021)

Transcriptome and lipidome profiling of COPD AMs revealed GOLD grade-dependent changes, such as in cholesterol metabolism and interferon-α and γ responses.

Keyphrases

single cell
rna seq
chronic obstructive pulmonary disease
lung function
dendritic cells
adipose tissue
cystic fibrosis
low density lipoprotein
fatty acid
air pollution
immune response