Retinoic acid-induced 2 (RAI2) is a novel tumor suppressor, and promoter region methylation of RAI2 is a poor prognostic marker in colorectal cancer.

Wenji YanKongming WuJames G HermanXiuduan XuYunsheng YangGuanghai DaiMingzhou Guo

Published in: Clinical epigenetics (2018)

RAI2 is frequently methylated in human CRC, and the expression of RAI2 is regulated by promoter region methylation. Methylation of RAI2 is an independent poor prognostic marker of CRC. RAI2 suppresses CRC cell growth both in vitro and in vivo. RAI2 suppresses CRC by inhibiting AKT signaling.

Keyphrases

dna methylation
signaling pathway
genome wide
gene expression
endothelial cells
transcription factor
poor prognosis
cell proliferation
high glucose
binding protein
induced pluripotent stem cells