Development of Polymer-Based Nanoformulations for Glioblastoma Brain Cancer Therapy and Diagnosis: An Update.
Bijuli RabhaKaushik Kumar BharadwajSiddhartha PatiBhabesh Kumar ChoudhuryTanmay SarkarZulhisyam Abdul KariHisham Atan EdinurDebabrat BaishyaLeonard Ionuţ AtanasePublished in: Polymers (2021)
Brain cancers, mainly high-grade gliomas/glioblastoma, are characterized by uncontrolled proliferation and recurrence with an extremely poor prognosis. Despite various conventional treatment strategies, viz., resection, chemotherapy, and radiotherapy, the outcomes are still inefficient against glioblastoma. The blood-brain barrier is one of the major issues that affect the effective delivery of drugs to the brain for glioblastoma therapy. Various studies have been undergone in order to find novel therapeutic strategies for effective glioblastoma treatment. The advent of nanodiagnostics, i.e., imaging combined with therapies termed as nanotheranostics, can improve the therapeutic efficacy by determining the extent of tumour distribution prior to surgery as well as the response to a treatment regimen after surgery. Polymer nanoparticles gain tremendous attention due to their versatile nature for modification that allows precise targeting, diagnosis, and drug delivery to the brain with minimal adverse side effects. This review addresses the advancements of polymer nanoparticles in drug delivery, diagnosis, and therapy against brain cancer. The mechanisms of drug delivery to the brain of these systems and their future directions are also briefly discussed.
Keyphrases
- drug delivery
- cancer therapy
- resting state
- white matter
- poor prognosis
- high grade
- functional connectivity
- cerebral ischemia
- long non coding rna
- stem cells
- type diabetes
- emergency department
- high resolution
- metabolic syndrome
- squamous cell carcinoma
- brain injury
- radiation therapy
- bone marrow
- drug release
- locally advanced
- fluorescence imaging
- mesenchymal stem cells
- insulin resistance
- mass spectrometry
- signaling pathway
- working memory
- young adults
- radiation induced
- coronary artery bypass
- case control