Deregulation of the non-coding genome in leukemia.
Susanna TeppoMerja HeinäniemiOlli LohiPublished in: RNA biology (2017)
Methodological advances that allow deeper characterization of non-coding elements in the genome have started to reveal the full spectrum of deregulation in cancer. We generated an inducible cell model to track transcriptional changes after induction of a well-known leukemia-inducing fusion gene, ETV6-RUNX1. Our data revealed widespread transcriptional alterations outside coding elements in the genome. This adds to the growing list of various alterations in the non-coding genome in cancer and pinpoints their role in diseased cellular state.
Keyphrases
- genome wide
- papillary thyroid
- single cell
- transcription factor
- acute myeloid leukemia
- gene expression
- squamous cell
- bone marrow
- dna methylation
- acute lymphoblastic leukemia
- copy number
- squamous cell carcinoma
- stem cells
- lymph node metastasis
- cell therapy
- machine learning
- childhood cancer
- young adults
- heat stress
- genome wide identification