Five-Year Analysis of Adjuvant Dabrafenib plus Trametinib in Stage III Melanoma.
Reinhard DummerAxel HauschildMario SantinamiVictoria AtkinsonMario MandalàJohn M KirkwoodVanna Chiarion SileniJames LarkinMarta NyakasCaroline DutriauxAndrew HaydonCaroline RobertLaurent MortierJacob SchachterThierry LesimpleRuth PlummerKohinoor DasguptaEduard GasalMonique TanGeorgina V LongDirk SchadendorfPublished in: The New England journal of medicine (2020)
In the 5-year follow-up of a phase 3 trial involving patients who had resected stage III melanoma with BRAF V600E or V600K mutations, 12 months of adjuvant therapy with dabrafenib plus trametinib resulted in a longer duration of survival without relapse or distant metastasis than placebo with no apparent long-term toxic effects. (Funded by GlaxoSmithKline and Novartis; COMBI-AD ClinicalTrials.gov number, NCT01682083; EudraCT number, 2012-001266-15.).