Glabridin reduces neuroinflammation by modulating inflammatory signals in LPS-induced in vitro and in vivo models.
Jiyu WengYing WangZekai TanYanghe YuanShiyuan HuangZexi LiYiming LiLanyue ZhangZhiyun DuPublished in: Inflammopharmacology (2024)
Glabridin can significantly reduce or even reverse LPS-induced neuroinflammation, which may be related to the fact that glabridin can reduce the NO expression, NF-κB, IBA-1, GFAP, and other inflammatory mediators, upregulate the expression of SOD to relieve oxidative stress of brain and inhibit the activation of gliocyte in brain tissue.
Keyphrases
- lps induced
- oxidative stress
- inflammatory response
- poor prognosis
- resting state
- white matter
- lipopolysaccharide induced
- long non coding rna
- dna damage
- cerebral ischemia
- binding protein
- signaling pathway
- ischemia reperfusion injury
- functional connectivity
- multiple sclerosis
- induced apoptosis
- cell proliferation
- immune response