Microbial dysbiosis in a mouse model of atopic dermatitis mimics shifts in human microbiome and correlates with the key pro-inflammatory cytokines IL-4, IL-33 and TSLP.
Y AmarE SchneiderM KöberleT SeeholzerS MusiolI M HölgeS GschwendtnerD KrappmannK SteigerT BiedermannC B Schmidt-WeberFrancesca AlessandriniPublished in: Journal of the European Academy of Dermatology and Venereology : JEADV (2022)
In this article, we show that (a) the model of choice to investigate AD needs to be characterized for the cutaneous microbiota if applicable and (b) the oxazolone-mediated mixed Th1-Th2 immune response triggers microbiota-induced alterations which share similarities to dysbiosis in human AD and represents therefore a suitable model for translational research on AD if alterations of the microbiome are in the focus of the investigation.