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Microbial dysbiosis in a mouse model of atopic dermatitis mimics shifts in human microbiome and correlates with the key pro-inflammatory cytokines IL-4, IL-33 and TSLP.

Y AmarE SchneiderM KöberleT SeeholzerS MusiolI M HölgeS GschwendtnerD KrappmannK SteigerT BiedermannC B Schmidt-WeberFrancesca Alessandrini
Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2022)
In this article, we show that (a) the model of choice to investigate AD needs to be characterized for the cutaneous microbiota if applicable and (b) the oxazolone-mediated mixed Th1-Th2 immune response triggers microbiota-induced alterations which share similarities to dysbiosis in human AD and represents therefore a suitable model for translational research on AD if alterations of the microbiome are in the focus of the investigation.
Keyphrases
  • endothelial cells
  • immune response
  • mouse model
  • atopic dermatitis
  • high glucose
  • induced pluripotent stem cells
  • pluripotent stem cells
  • microbial community
  • diabetic rats
  • dendritic cells
  • decision making