Effect of concomitant medications on treatment response and survival in non-metastatic castrate resistant prostate cancer: Exploratory analysis of the SPARTAN trial.
Soumyajit RoyFred SaadYilun SunShawn MaloneDaniel E SprattAmar U KishanChristopher J D WallisAngela Y JiaOsama MohamadUmang SwamiMichael OngNeeraj AgarwalSimon ChowdhuryScott C MorganPublished in: European journal of cancer (Oxford, England : 1990) (2024)
In this post-hoc exploratory analysis of SPARTAN, effects of apalutamide on MFS and OS were consistent across subgroups stratified by exposure to concomitant medications. Exposure to concomitant metformin and ACEI was independently associated with a significant improvement in MFS.