Hyperglycemia affects global 5-methylcytosine and 5-hydroxymethylcytosine in blood genomic DNA through upregulation of SIRT6 and TETs.

Er-Feng YuanYing YangLin ChengXujing DengShao-Min ChenXin ZhouSong-Mei Liu

Published in: Clinical epigenetics (2019)

Hyperglycemia appeared to promote the mRNA expression of SIRT6 and TETs, which in turn might cause the dynamic changes of 5mC and 5hmC in WBCs from T2DM patients.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
oxidative stress
chronic kidney disease
ischemia reperfusion injury
cell proliferation
poor prognosis
signaling pathway
circulating tumor
type diabetes
adipose tissue
cell free
single molecule
gene expression
genome wide