Comprehensive network modeling from single cell RNA sequencing of human and mouse reveals well conserved transcription regulation of hematopoiesis.

Shouguo GaoZhijie WuXingmin FengSachiko KajigayaXujing WangNeal S Young

Published in: BMC genomics (2020)

Transcriptional regulatory networks are well conserved between human and mouse. The hierarchical organization of transcription factors may provide insights into hematopoietic cell lineage commitment, and to signal processing, cell survival and disease initiation.

Keyphrases

single cell
transcription factor
rna seq
endothelial cells
induced pluripotent stem cells
high throughput
dna binding
pluripotent stem cells
gene expression
oxidative stress
heat shock protein