TLR-2 expression and dysregulated human Treg/Th17 phenotype in Aspergillus flavus infected patients of chronic rhinosinusitis with nasal polyposis.
Gargi RaiShukla DasMohammad Ahmad AnsariPraveen Kumar SinghSajad Ahmad DarShafiul HaqueNeelima GuptaSonal SharmaVishnampettai Ganapathysubramanian RamachandranSanskriti SharmaCharu JainShipra SharmaPublished in: Microbial cell factories (2020)
Our data highlights the excessive expression of TLR-2 in nasal polyps contributing to the imbalance in Th17/Tregs population in patients. After therapy, recovery of Tregs cells indicates restoration and tissue homeostasis, though high circulating CD4+CD161+ Th17 cells may continue to be a threat to patients predisposed to future recurrences. The constant exposure and tendency of A. flavus to colonize nasal cavities can lead to a Th17 driven airway inflammation. Dysregulated Th17 with TLR-2 promote resistance to treatment and progression to the chronicity of the disease.
Keyphrases
- chronic rhinosinusitis
- end stage renal disease
- toll like receptor
- newly diagnosed
- poor prognosis
- induced apoptosis
- immune response
- inflammatory response
- chronic kidney disease
- prognostic factors
- endothelial cells
- cell cycle arrest
- oxidative stress
- physical activity
- stem cells
- bone marrow
- patient reported outcomes
- mesenchymal stem cells
- body mass index
- binding protein
- cell proliferation
- long non coding rna
- nuclear factor
- deep learning
- artificial intelligence
- current status
- smoking cessation
- combination therapy