Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis.
Mark C BlaserFabrizio BuffoloArda HaluMandy E TurnerFlorian SchlotterHideyuki HigashiLorena PantanoCassandra L CliftLouis A SaddicSamantha K AtkinsMaximillian A RogersTan PhamAmélie VrommanEugenia ShvartzGalina K SukhovaSilvia MonticoneGiovanni CamussiSimon C RobsonSimon C BodyJochen D MuehlschlegelSasha A SinghMasanori AikawaElena AikawaPublished in: Circulation (2023)
The first comparative proteomics study of human carotid artery plaques and calcified aortic valves identifies unique drivers of atherosclerosis versus aortic valve stenosis and implicates EVs in advanced cardiovascular calcification. We delineate a vesiculomics strategy to isolate, purify, and study protein and RNA cargoes from EVs entrapped in fibrocalcific tissues. Integration of vesicular proteomics and transcriptomics by network approaches revealed novel roles for tissue EVs in modulating cardiovascular disease.
Keyphrases
- aortic valve
- transcatheter aortic valve replacement
- cardiovascular disease
- transcatheter aortic valve implantation
- aortic valve replacement
- aortic stenosis
- mass spectrometry
- genome wide
- gene expression
- single cell
- dna methylation
- coronary artery
- chronic kidney disease
- signaling pathway
- atrial fibrillation
- induced pluripotent stem cells
- ejection fraction
- coronary artery disease
- network analysis
- protein protein