The influence of Nrf2 gene promoter methylation on gene expression and oxidative stress parameters in preeclampsia.

Saba Zakeri Zohreh Rahimi Nayebali RezvaniAsad Vaisi-RayganiReza AlibakhshiSahel ZakeriKheirolah Yari

Published in: BMC medical genomics (2024)

The Nrf2 gene undergoes epigenetic modifications of DNA hypermethylation in the PE placenta. Decreased expression of this gene and the changes in the level of oxidative parameters (TAC, TOS) confirm it.

Keyphrases

gene expression
oxidative stress
dna methylation
genome wide
copy number
genome wide identification
poor prognosis
dna damage
transcription factor
early onset
single molecule
pregnant women
binding protein
genome wide analysis
endoplasmic reticulum stress
heat stress