Single-cell Profiling Uncovers a Muc4 -Expressing Metaplastic Gastric Cell Type Sustained by Helicobacter pylori -driven Inflammation.

Valerie P O'Brien Yuqi Kang Meera K Shenoy Greg Finak William C Young Julien Dubrulle Lisa K Koch Armando E Rodriguez Martinez Jeffery Williams Elizabeth Donato Surinder Kumar Batra Cecilia C S Yeung William M Grady Meghan A Koch Raphaël Gottardo Nina R Salama

Published in: Cancer research communications (2023)

-driven inflammation. In humans, metaplastic pit cells show enhanced proliferation as well as enrichment in precancer and early cancer tissues, highlighting an early step in the gastric metaplasia to cancer cascade.

Keyphrases

helicobacter pylori
single cell
papillary thyroid
oxidative stress
induced apoptosis
squamous cell
helicobacter pylori infection
signaling pathway
gene expression
rna seq
cell cycle arrest
high throughput
lymph node metastasis
squamous cell carcinoma
cell death
endoplasmic reticulum stress
pi k akt