Mass spectrometric profiling of DNA adducts in the human stomach associated with damage from environmental factors.
Ippei OhnishiYuji IwashitaYuto MatsushitaShunsuke OhtsukaTakashi YamashitaKeisuke InabaAtsuko FukazawaHideto OchiaiKeigo MatsumotoNobuhito KuronoYoshitaka MatsushimaHiroki MoriShioto SuzukiShohachi SuzukiFumihiko TaniokaHaruhiko SugimuraPublished in: Genes and environment : the official journal of the Japanese Environmental Mutagen Society (2021)
We characterized 7 DNA adducts in the nontumor portion of the human stomach in both gastric cancer subjects and nongastric cancer subjects. A reduction in C5-hydroxymethyl-dC even in the nontumor mucosa of patients with gastric cancer was observed. Smoking and drinking habits significantly influenced the quantity of one of the lipid peroxidation-derived adducts, etheno-dA. A more expansive DNA adductome profile would provide a comprehensive understanding of the origin of human cancer in the future.