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Opioid-free anesthesia versus opioid-based anesthesia in patients undergoing cardiovascular and thoracic surgery: a meta-analysis and systematic review.

Dave M MathewPeter J FuscoKathryn S VargheseAhmed K AwadEamon VegaSerena M MathewMia PolizziJerrin GeorgeChristopher S MathewJeremiah J ThomasRose CalixteAdham Ahmed
Published in: Seminars in cardiothoracic and vascular anesthesia (2023)
Through the first pooled analysis of OBA vs OFA in a cardiothoracic-exclusive cohort, we found no significant difference in any of the pooled outcomes for thoracic surgery patients. Although limited to 2 cardiovascular surgery studies, OFA was associated with significantly reduced postoperative nausea and vomiting, inotrope need, and non-invasive ventilation in these patients. With growing use of OFA in invasive operations, further studies are needed to assess their efficacy and safety in cardiothoracic patients.
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