Intersite brain MRI volumetric biases persist even in a harmonized multisubject study of multiple sclerosis.
Kelly A ClarkCarly M O'DonnellMark A ElliottShahamat TauhidBlake E DeweyRenxin ChuSamar KhalilGovind NairPascal SatiAnna DuValNicole PellegriniAmit Bar-OrClyde MarkowitzMatthew K SchindlerJonathan ZurawskiPeter A CalabresiDaniel S ReichRohit BakshiRussell Taki Shinoharanull nullPublished in: Journal of neuroimaging : official journal of the American Society of Neuroimaging (2023)
Differences in brain volumetry persisted across MR scanners despite protocol harmonization. These differences were not well explained by variance component modeling; however, statistical innovations for mitigating intersite differences show promise in reducing biases in multicenter studies of MS.