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Immune checkpoint gene signature assesses immune infiltration profiles in bladder cancer and identifies KRT23 as an immunotherapeutic target.

Dongshan ChenHaoyuan CaoXiang ZhengHaojun WangZengchi HanWei Wang
Published in: BMC cancer (2024)
This study systematically and comprehensively analyzed the expression profile of immune checkpoint genes, and established the ICG signature to investigate the differences in ICGs expression and tumor immune microenvironment, which will help risk stratification and accelerate precision medicine. Finally, we identified KRT23 as the most critical model gene, and highlighted KRT23 as a potential target to enhance immunotherapy against BLCA.
Keyphrases
  • genome wide
  • genome wide identification
  • copy number
  • dna methylation
  • poor prognosis
  • genome wide analysis
  • transcription factor
  • fluorescence imaging
  • risk assessment