The lipopolysaccharide-TLR4 axis regulates hepatic glutaminase 1 expression promoting liver ammonia build-up as steatotic liver disease progresses to steatohepatitis.

Maria Mercado-GómezNaroa Goikoetxea-UsandizagaAnnarein J C KerbertLeire Uraga GracianteparalucetaMarina Serrano-MaciáSofia Lachiondo-OrtegaRubén Rodriguez-AgudoClàudia Gil-PitarchJorge SimónIrene González-RecioMarcos F FondevilaPablo Santamarina-OjedaMario F FragaRubén NogueirasJavier de Las HerasRajiv JalanMaría Luz Martínez-ChantarTeresa C Delgado

Published in: Metabolism: clinical and experimental (2024)

Overall, our results suggest that the LPS/TLR4 axis regulates hepatic GLS expression promoting liver ammonia build-up as steatotic liver disease progresses to steatohepatitis.

Keyphrases

inflammatory response
toll like receptor
poor prognosis
immune response
lps induced
binding protein
room temperature
anaerobic digestion
nuclear factor
ionic liquid