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Parkinson's disease determinants, prediction and gene-environment interactions in the UK Biobank.

Benjamin Meir JacobsDaniel BeleteJonathan BestwickCornelis BlauwendraatSara Bandres-CigaKarl HeilbronChu-Yueh GuoMike A NallsAndrew B SingletonJohn HardyGavin GiovannoniAndrew John LeesAnette-Eleonore SchragAlastair J Noyce
Published in: Journal of neurology, neurosurgery, and psychiatry (2021)
Here, we used UK Biobank data to reproduce several well-known associations with PD, to demonstrate the validity of a PRS and to demonstrate a novel gene-environment interaction, whereby the effect of diabetes on PD risk appears to depend on background genetic risk for PD.
Keyphrases
  • genome wide
  • copy number
  • type diabetes
  • cardiovascular disease
  • cross sectional
  • electronic health record
  • machine learning
  • glycemic control
  • skeletal muscle