Parkinson's disease determinants, prediction and gene-environment interactions in the UK Biobank.
Benjamin Meir JacobsDaniel BeleteJonathan BestwickCornelis BlauwendraatSara Bandres-CigaKarl HeilbronChu-Yueh GuoMike A NallsAndrew B SingletonJohn HardyGavin GiovannoniAndrew John LeesAnette-Eleonore SchragAlastair J NoycePublished in: Journal of neurology, neurosurgery, and psychiatry (2021)
Here, we used UK Biobank data to reproduce several well-known associations with PD, to demonstrate the validity of a PRS and to demonstrate a novel gene-environment interaction, whereby the effect of diabetes on PD risk appears to depend on background genetic risk for PD.