Parkinson's disease determinants, prediction and gene-environment interactions in the UK Biobank.

Benjamin Meir Jacobs Daniel BeleteJonathan BestwickCornelis BlauwendraatSara Bandres-CigaKarl HeilbronChu-Yueh GuoMike A NallsAndrew B SingletonJohn HardyGavin Giovannoni Andrew John Lees Anette-Eleonore Schrag Alastair J Noyce

Published in: Journal of neurology, neurosurgery, and psychiatry (2021)

Here, we used UK Biobank data to reproduce several well-known associations with PD, to demonstrate the validity of a PRS and to demonstrate a novel gene-environment interaction, whereby the effect of diabetes on PD risk appears to depend on background genetic risk for PD.

Keyphrases

genome wide
copy number
type diabetes
cardiovascular disease
cross sectional
electronic health record
machine learning
glycemic control
skeletal muscle