Real World Clinical Utility of Neurophysiological Measurement Utilizing Closed-Loop Spinal Cord Stimulation in a Chronic Pain Population: The ECAP Study Protocol.
Angela LeitnerErin HansonNicole SolidayPeter StaatsRobert LevyJason PopeJan W KallewaardDaniel DoleysSean LiJacqueline Soicher WeisbeinKasra AmirdelfanLawrence R PoreePublished in: Journal of pain research (2023)
Associations between objective neurophysiological data, clinical evaluation and patient-reported outcomes may have important clinical and scientific implications. They may provide novel insights about the chronic pain pathophysiology, its modulation during CL-SCS, and identification of pain phenotypes and/or mechanisms associated with treatment response during SCS trials and long-term therapy. Data from the ECAP study could lead to improvements in diagnosis, assessment, patient identification and management of chronic pain. It could also provide the foundation for development of a new SCS treatment approach customized by the patient's pain phenotype, unique neurophysiology, and disease severity.
Keyphrases
- chronic pain
- patient reported outcomes
- clinical evaluation
- spinal cord
- pain management
- case report
- study protocol
- electronic health record
- big data
- randomized controlled trial
- clinical trial
- spinal cord injury
- bioinformatics analysis
- neuropathic pain
- stem cells
- machine learning
- open label
- data analysis
- mesenchymal stem cells
- artificial intelligence
- smoking cessation
- deep learning