The paradox role of caspase cascade in ionizing radiation therapy.
Najmeh RahmanianSeyed Jalal HosseinimehrAli KhalajPublished in: Journal of biomedical science (2016)
Radiotherapy alone or in combination with chemotherapy/surgery is widely used for treatment of cancers. It reduces tumor growth and prevents metastasis. While ionizing radiation activates caspase cascade resulted in apoptosis in cancer cells, it also stimulates tumor cell re-population that leads to reduce the effectiveness of the radiation therapy. This review describes the mechanisms for paradox role of caspase cascade in cancer therapy and discusses the logical and practical strategies for improvement the therapeutic index of radiotherapy through enhancement of radiosensitivity and decreasing the rate of tumor recurrence.
Keyphrases
- radiation therapy
- cell death
- locally advanced
- induced apoptosis
- cancer therapy
- early stage
- endoplasmic reticulum stress
- radiation induced
- cell cycle arrest
- rectal cancer
- oxidative stress
- minimally invasive
- randomized controlled trial
- squamous cell carcinoma
- systematic review
- cell therapy
- drug delivery
- coronary artery bypass
- stem cells
- signaling pathway
- mouse model
- free survival
- mesenchymal stem cells
- replacement therapy