Pulmonary Artery Pseudoaneurysm in COVID-19-Associated Pulmonary Mucormycosis: Case Series and Systematic Review of the Literature.
Himanshu PruthiValliappan MuthuHarish BhujadeArun SharmaAbhiman BalojiRao G RatnakaraAmanjit BalHarkant SinghManavjit Singh SandhuSunder NegiArunaloke ChakrabartiManphool SinghalPublished in: Mycopathologia (2021)
Literature on COVID-19-associated pulmonary mucormycosis (CAPM) is sparse. Pulmonary artery pseudoaneurysm (PAP) is an uncommon complication of pulmonary mucormycosis (PM), and rarely reported in CAPM. Herein, we report five cases of CAPM with PAP managed at our center and perform a systematic review of the literature. We diagnosed PM in those with clinico-radiological suspicion and confirmed it by microbiology or histopathology. We encountered five cases of CAPM with PAP (size ranged from 1 × 0.8 cm to ~ 4.9 × 4.8 cm). All subjects had diabetes and were aged 55-62 years (75% men). In two cases, COVID-19 and mucormycosis were diagnosed simultaneously, while in three others, COVID-19 preceded PM. One subject who underwent surgery survived, while all others died (80% mortality). From our systematic review, we identified one additional case of CAPM with PAP in a transplant recipient. CAPM with PAP is rare with high mortality. Early diagnosis and multimodality management are imperative to improve outcomes.
Keyphrases
- pulmonary artery
- pulmonary hypertension
- coronavirus disease
- sars cov
- systematic review
- coronary artery
- pulmonary arterial hypertension
- particulate matter
- air pollution
- type diabetes
- cardiovascular events
- polycyclic aromatic hydrocarbons
- heavy metals
- respiratory syndrome coronavirus
- risk factors
- minimally invasive
- randomized controlled trial
- metabolic syndrome
- endovascular treatment
- meta analyses
- coronary artery bypass
- risk assessment
- acute coronary syndrome
- infectious diseases
- neural network