Suppression of tumor cell lactate-generating signaling pathways eradicates murine PTEN/p53-deficient aggressive-variant prostate cancer via macrophage phagocytosis.

Kiranj Chaudagar Hanna M Hieromnimon Anne Kelley Brian Labadie Jordan S Shafran Srikrishnan Rameshbabu Catherine Drovetsky Kaela M Bynoe Solanki Aniruddhsingh Erica Markiewicz Xiaobing Fan Massimo Loda Akash Patnaik

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

Abrogation of lactate-mediated cross-talk between cancer cells and TAM results in durable ADT-independent tumor control in PTEN/p53-deficient AVPC, and warrants further investigation in clinical trials.

Keyphrases

prostate cancer
pi k akt
clinical trial
cell proliferation
signaling pathway
single cell
adipose tissue
cell therapy
randomized controlled trial
epithelial mesenchymal transition
wild type
study protocol
phase iii