A transposable element into the human long noncoding RNA CARMEN is a switch for cardiac precursor cell specification.

Isabelle PlaisancePanagiotis ChouvardasYuliangzi SunMohamed NemirParisa AghagolzadehFarhang AminfarSophie ShenWoo Jun ShimFrancesca RochaisRory JohnsonNathan J Palpant Thierry Pedrazzini

Published in: Cardiovascular research (2022)

These data show how a critical physiological switch is wired by alternative splicing and functional transposable elements in a long noncoding RNA. They further demonstrated the crucial importance of the lncRNA isoform CARMEN-201 in SMC specification during heart development.

Keyphrases

long noncoding rna
endothelial cells
cell fate
single cell
heart failure
cell therapy
left ventricular
electronic health record
induced pluripotent stem cells
pluripotent stem cells
atrial fibrillation
data analysis