Effects of Long-Term Caffeine Consumption on the Adenosine A1 Receptor in the Rat Brain: an In Vivo PET Study with [18F]CPFPX.

Danje Nabbi-SchroeterDavid ElmenhorstAngela OskampStefanie LaskowskiAndreas BauerTina Kroll

Published in: Molecular imaging and biology (2019)

The present study provides evidence that chronic caffeine consumption does not lead to persistent changes in functional availability of cerebral A1ARs which have previously been associated with neuroprotective effects of caffeine. The acute and region-specific decrease in cerebral A1AR availability directly after caffeine withdrawal is most likely caused by residual amounts of caffeine metabolites disguising an unchanged A1AR expression at this early time-point.

Keyphrases

poor prognosis
subarachnoid hemorrhage
computed tomography
liver failure
respiratory failure
binding protein
acute respiratory distress syndrome
extracorporeal membrane oxygenation
protein kinase
mechanical ventilation