Aβ exacerbates α-synuclein-induced neurotoxicity through impaired insulin signaling in α-synuclein-overexpressed human SK-N-MC neuronal cells.
Ching-Chi ChangHsin-Hua LiYen-Ting ChangYing-Jui HoLing-Jia HsiehPai-Yi ChiuYu-Shih ChengChih-Li LinTe-Jen LaiPublished in: CNS neuroscience & therapeutics (2017)
This raised the possibility that insulin resistance could be one of the causative factors of αSyn toxicity, and the strategies for insulin sensitization may have therapeutic potential for synucleinopathies including DLB.
Keyphrases
- type diabetes
- insulin resistance
- glycemic control
- endothelial cells
- induced apoptosis
- high glucose
- cell cycle arrest
- oxidative stress
- diabetic rats
- adipose tissue
- metabolic syndrome
- high fat diet
- induced pluripotent stem cells
- pluripotent stem cells
- polycystic ovary syndrome
- cell death
- skeletal muscle
- drug induced
- signaling pathway
- cerebral ischemia