Patient-centered simulations to assess the usefulness of the 70-gene signature for adjuvant chemotherapy administration in early-stage breast cancer.

Emmanuel CaruanaYohann FoucherPhilippe TessierJean-Sébastien FrenelJean-Marc ClasseEtienne Dantan

Published in: Breast cancer research and treatment (2019)

Our results support the conclusions published by Cardoso et al. by providing additional evidence that the 70-gene signature can be used to avoid overtreatment by CT for women with high clinical risk but low genomic risk.

Keyphrases

early stage
copy number
genome wide
computed tomography
randomized controlled trial
squamous cell carcinoma
gene expression
magnetic resonance
dna methylation
radiation therapy
contrast enhanced
sentinel lymph node
image quality
young adults
meta analyses
breast cancer risk
monte carlo