Leptin in Human Milk-One of the Key Regulators of Nutritional Programming.
Elena Sinkiewicz-DarolIwona AdamczykKatarzyna ŁubiechGabriela PilarskaMagdalena TwarużekPublished in: Molecules (Basel, Switzerland) (2022)
Breast milk is the optimal food for infants and toddlers, providing basic nutrients. It is also a source of many biologically active substances. Among them are hormones responsible for metabolic balance. One of the hormones taken in with breast milk by a breastfed baby is leptin. This hormone is involved in the regulation of appetite, informing the brain about the body's energy resources. Having the correct mechanisms related to the action of leptin is a factor reducing the risk of obesity. The natural presence of leptin in the composition of breast milk suggests that it has a specific role in shaping the health of a breastfed child. Obesity as a disease of civilization affects more and more people, including children. The development of this disease is multifaceted and determined by many factors, including genetic and environmental factors such as eating habits and low physical activity. Behind obesity, there are complex mechanisms in which many elements of the human body are involved. Understanding the effects of breastfeeding as a natural source of leptin can help prevent childhood obesity and development of this disease in future life.
Keyphrases
- weight loss
- physical activity
- insulin resistance
- metabolic syndrome
- human milk
- type diabetes
- high fat diet induced
- weight gain
- mental health
- healthcare
- endothelial cells
- low birth weight
- preterm infants
- drinking water
- skeletal muscle
- transcription factor
- gene expression
- heavy metals
- current status
- resting state
- body weight
- functional connectivity
- copy number
- human health
- pluripotent stem cells