Drug delivery nanoparticles for preventing implant bacterial infections based on the bacteria and immunity mechanisms.
Chen ChenQi XiaoLeyi XiaoMengge FengFangzhe LiuKe YaoYu CuiTiange ZhangYu-Feng ZhangPublished in: Biomaterials science (2023)
Implant dysfunction and failure during medical treatment can be attributed to bacterial infection with Staphylococcus aureus and Enterococcus faecalis , which are the prevalent strains responsible for implant infections. Currently, antibiotics are primarily used either locally or systemically to prevent and treat bacterial infections in implants. However, the effectiveness of this approach is unsatisfactory. Therefore, the development of new antimicrobial medications is crucial to address the clinical challenges associated with implant infections. In this study, a nanoparticle (ICG+RSG) composed of indocyanine green (ICG) and rosiglitazone (RSG), and delivered using 1,2-dipalmitoyl-snglycero-3-phosphocholine (DPPC) was prepared. ICG+RSG has photothermal and photodynamic properties to eliminate bacteria at the infection site by releasing reactive oxygen species and increasing the temperature. Additionally, it regulates phagocytosis and macrophage polarization to modulate the immune response in the body. ICG+RSG kills bacteria and reduces tissue inflammation, showing potential for preventing implant infections.
Keyphrases
- soft tissue
- staphylococcus aureus
- drug delivery
- fluorescence imaging
- immune response
- reactive oxygen species
- cancer therapy
- oxidative stress
- randomized controlled trial
- healthcare
- escherichia coli
- photodynamic therapy
- systematic review
- dendritic cells
- climate change
- toll like receptor
- methicillin resistant staphylococcus aureus
- human health