A phase 1 trial of the safety, tolerability and biological effects of intravenous Enadenotucirev, a novel oncolytic virus, in combination with chemoradiotherapy in locally advanced rectal cancer (CEDAR).

Sean Michael O'CathailSteven DavisJane HolmesRichard BrownKerry FisherLeonard SeymourRichard AdamsJames GoodDavid Sebag-MontefioreTim MaughanMaria A Hawkins

Published in: Radiation oncology (London, England) (2020)

ClinicalTrial.gov, NCT03916510. Registered 16th April 2019.

Keyphrases

locally advanced
rectal cancer
neoadjuvant chemotherapy
phase ii study
open label
squamous cell carcinoma
high dose
radiation therapy
double blind
randomized controlled trial
low dose
disease virus