Toward precision therapeutics: general and specific factors differentiate symptom change in depressed adolescents.
Madison AitkenJohn D HaltiganPeter SzatmariBernadka DubickaFonagy PRaphael KelvinNick MidgleyShirley ReynoldsPaul O WilkinsonIan Michael GoodyerPublished in: Journal of child psychology and psychiatry, and allied disciplines (2020)
The clinical response signature in this trial is best revealed by rapid reductions in depression symptoms and general psychopathology. Protracted improvements in general psychopathology and conduct problems subsequently occur. Psychosocial treatments for adolescent depression have comparable effects on general and specific psychopathology, although a psychoeducational, goal-focused approach may be indicated for youth with comorbid conduct problems.