MicroRNA (miR)-124: A Promising Therapeutic Gateway for Oncology.
Karthik GourishettiVignesh Balaji EYoussef MostakimKarkala Sreedhara Ranganath PaiDeepak BherePublished in: Biology (2023)
MicroRNA (miR) are a class of small non-coding RNA that are involved in post-transcriptional gene regulation. Altered expression of miR has been associated with several pathological conditions. MicroRNA-124 (miR-124) is an abundantly expressed miR in the brain as well as the thymus, lymph nodes, bone marrow, and peripheral blood mono-nuclear cells. It plays a key role in the regulation of the host immune system. Emerging studies show that dysregulated expression of miR-124 is a hallmark in several cancer types and it has been attributed to the progression of these malignancies. In this review, we present a comprehensive summary of the role of miR-124 as a promising therapeutic gateway in oncology.
Keyphrases
- cell proliferation
- long non coding rna
- long noncoding rna
- poor prognosis
- bone marrow
- lymph node
- peripheral blood
- palliative care
- gene expression
- mesenchymal stem cells
- induced apoptosis
- oxidative stress
- early stage
- young adults
- cell death
- brain injury
- resting state
- papillary thyroid
- lymph node metastasis
- rectal cancer