Adult Low-Hypodiploid Acute Lymphoblastic Leukemia Emerges from Preleukemic TP53-Mutant Clonal Hematopoiesis.
Rathana KimHugo BergugnatLise LarcherMatthieu DuchmannMarie PassetStéphanie GachetWendy CuccuiniMarina Lafage-PochitaloffCédric PastoretNathalie GrardelVahid AsnafiBeat W SchäferEric DelabesseRaphaël A ItzyksonLionel AdesYosr HicheriYves ChalandonCarlos GrauxPatrice ChevallierMathilde M Hunault-BergerThibaut Tl LeguayFrançoise HuguetVéronique LhéritierHervé DombretJean SoulierPhilippe RousselotNicolas BoisselEmmanuelle ClappierPublished in: Blood cancer discovery (2023)
We show that low-hypodiploid ALL is a frequent entity within B-ALL in older adults, relying on somatic TP53 biallelic alteration. Our study unveils a link between aging and low-hypodiploid ALL, with TP53-mutant clonal hematopoiesis representing a preleukemic reservoir that can give rise to aneuploidy and B-ALL. See related commentary by Saiki and Ogawa, p. 102. This article is highlighted in the In This Issue feature, p. 101.