Oxidized phospholipids affect small intestine neuromuscular transmission and serotonergic pathways in juvenile mice.

Ilaria Marsilio Valentina Caputi Eva Latorre Silvia CerantolaAndrea PaquolaAna I AlcaldeJose Emilio Mesonero Siobhain M O'MahonyAntonella BertazzoCristina Giaroni Maria Cecilia Giron

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2020)

OxPAPC treatment disrupted structural and functional integrity of the ENS, affecting serotoninergic tone and 5-HT tissue levels toward a higher kynurenine content during adolescence, suggesting that changes in intestinal lipid metabolism toward oxidation can affect serotoninergic pathways, potentially increasing the risk of developing functional gastrointestinal disorders during critical stages of development.

Keyphrases

fatty acid
depressive symptoms
high fat diet induced
type diabetes
skeletal muscle
wild type
smoking cessation