Low-dose methadone for refractory chronic migraine accompanied by medication-overuse headache: a prospective cohort study.

Silvia BenemeiChiara LupiFrancesco De CesarisNiccolò LombardiAlessandra BettiolAlberto ChiarugiPierangelo GeppettiValentina GalliChiara PracucciBrunella OccupatiGuido Mannaioni

Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2020)

LDM could represent a valuable and effective option in selected patients affected by RCM with continuous headache and MOH, although the frequency of early ADRs poses major safety concerns. Randomized controlled trials are needed to confirm the efficacy and safety of LDM prophylaxis.

Keyphrases

low dose
end stage renal disease
randomized controlled trial
chronic kidney disease
peritoneal dialysis
high dose
prognostic factors
clinical trial