Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma.
Takahide NejoLin WangKevin K LeungAlbert WangSenthilnath LakshmanachettyMarco GallusDarwin W KwokChibo HongLee H ChenDiego A CarreraMichael Y ZhangNicholas O SteversGabriella C MaldonadoAkane YamamichiPayal WatchmakerAkul NaikAnny ShaiJoanna J PhillipsSusan M ChangArun P WiitaJames A WellsJoseph F CostelloAaron A DiazHideho OkadaPublished in: bioRxiv : the preprint server for biology (2023)
Our investigation illustrated the diverse characteristics of the tumor-specific AS events and the challenges of antigen exploration due to their notable spatiotemporal heterogeneity and elusive nature at the protein levels. Redirecting future efforts toward intracellular, MHC-presented antigens could offer a more viable avenue.