Intratumoral Heterogeneity of SMAD4 Immunohistochemical Expression and Its Role in Prediction of Recurrence Pattern in Patients with Resectable Pancreatic Cancer.

Ilya PokataevAsel KudaibergenovaAnna ArtemyevaAnna PopovaAlexey RumyantsevDanil PodluzhnyNikolay KudashkinMikhail FedyaninAlexey TryakinSergey Tjulandin

Published in: Journal of gastrointestinal cancer (2020)

Different areas inside primary tumor and lymph node metastases express SMAD4 heterogeneously. SMAD4 IHC expression is not a biomarker of the recurrence pattern after surgical resection for PC.

Keyphrases

lymph node
epithelial mesenchymal transition
transforming growth factor
poor prognosis
free survival
binding protein
neoadjuvant chemotherapy
squamous cell carcinoma
radiation therapy