Reduced subgenomic RNA expression is a molecular indicator of asymptomatic SARS-CoV-2 infection.
Chee Hong WongChew Yee NganRachel L GoldfederJennifer IdolChris KuhlbergRahul MauryaKevin KellyGregory OmerzaNicholas RenzetteFrancine De AbreuLei LiFrederick A BrowneEdison T LiuChia-Lin WeiPublished in: Communications medicine (2021)
Our results indicate that differential sgRNA expression and structural mutational burden are highly correlated with the clinical severity of SARS-CoV-2 infection. Longitudinally monitoring sgRNA expression and structural diversity could further guide treatment responses, testing strategies, and vaccine development.