Divergent tumor and immune cell reprogramming underlying immunotherapy response and immune-related adverse events in lung squamous cell carcinoma.
Min-Jiang ChenPengfei MaYong-Chang ZhangDong WangZhuang YuYujie FuXiaojing ZhaoMengzhao WangGuanglei ZhuangYing JingPublished in: Journal for immunotherapy of cancer (2023)
Our data depicts specific reprogramming of macrophage, T cells and tumor cells associated with ICI response and irAEs, elucidates divergent roles of TNF signaling in antitumor immunity and irAEs, and highlights the significance of TNF expression in irAE development in the LUSC setting.