Neutrophils Protect Against Staphylococcus aureus Endocarditis Progression Independent of Extracellular Trap Release.
Severien MeyersMarleen LoxSirima KraisinLaurens LiesenborghsCaroline P MartensLiesbeth FrederixStijn Van BruggenMarilena CrescenteDominique MissiakasPieter BaatsenThomas VanasschePeter VerhammeKimberly MartinodPublished in: Arteriosclerosis, thrombosis, and vascular biology (2022)
coagulases, but not nucleases, reduced IE severity and increased NET levels. Staphylocoagulase-induced fibrin likely hampers NETs from constraining infection and the resultant tissue damage, a hallmark of valve destruction in IE.