Evidence for sex-specific intramuscular changes associated to physical weakness in adults older than 75 years.
Jelle C B C de JongLars VerschurenMartien P M CaspersMarjanne D van der HoekFeike R van der LeijRobert KleemannAnita M van den HoekArie G NieuwenhuizenJaap KeijerPublished in: Biology of sex differences (2023)
• In female, but not male older adults, physical weakness was associated with a higher expression of intramuscular markers for inflammation. • In male, but not female older adults, physical weakness was associated with a smaller diameter of type 2 (fast) myofibers and lower PRKN expression. • Fit older adults (of both sexes) maintained expression levels comparable to young participants of weakness related genes, differing from frail participants.