Hematopoiesis: a BETter understanding.
Nirmalya DasguptaPeter D AdamsPublished in: EMBO reports (2023)
Epigenetic modifications are known to be crucial for hematopoietic stem cell (HSC) differentiation, with the BET family member BRD4 playing a vital role in this as an epigenetic reader. In this issue of EMBO reports, Yang et al (2023) demonstrate that the absence of BRD4 leads to senescence in HSCs and hematopoietic progenitor cells (HPCs), affecting the expression of crucial genes involved in myeloid and erythroid development. These data suggest that BRD4 has a protective role in preserving histone tails, thereby sustaining normal HSC/HPC functions.
Keyphrases
- hematopoietic stem cell
- dna methylation
- bone marrow
- gene expression
- poor prognosis
- dendritic cells
- acute myeloid leukemia
- electronic health record
- endothelial cells
- big data
- binding protein
- stress induced
- immune response
- adverse drug
- oxidative stress
- emergency department
- artificial intelligence
- deep learning
- data analysis