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Therapeutic mechanisms of psilocybin: Changes in amygdala and prefrontal functional connectivity during emotional processing after psilocybin for treatment-resistant depression.

Lea J MertensMatthew B WallLeor RosemanLysia DemetriouDavid J NuttRobin Lester Carhart-Harris
Published in: Journal of psychopharmacology (Oxford, England) (2020)
These results are consistent with the idea that psilocybin therapy revives emotional responsiveness on a neural and psychological level, which may be a key treatment mechanism for psychedelic therapy. Future larger placebo-controlled studies are needed to examine the replicability of the current findings.
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