Endogenous TLR2 ligand embedded in the catalytic region of human cysteinyl-tRNA synthetase 1.

Seongmin ChoSang Bum KimYoungjin LeeEe Chan SongUijoo KimHyeong Yun KimJi Hun SuhPeter C GoughnourYounHa KimIna YoonNa Young ShinDoyeun KimIl-Kyu KimChang-Yuil KangSong Yee JangMyung Hee KimSunghoon Kim

Published in: Journal for immunotherapy of cancer (2021)

We identified the endogenous TLR2/6 activating domain from human cysteinyl-tRNA synthetase CARS1. This novel TLR2/6 ligand showed potent immune-stimulating activity with little toxicity. Thus, the UNE-C1 domain can be developed as an effective immunoadjuvant with checkpoint inhibitors or cancer antigens to boost antitumor immunity.

Keyphrases

toll like receptor
endothelial cells
inflammatory response
immune response
induced pluripotent stem cells
pluripotent stem cells
signaling pathway
dna damage
papillary thyroid
oxidative stress
dendritic cells
cell proliferation
squamous cell
anti inflammatory