Development and synthesis of a novel salen-type ligand based on phenylalanine for Mizoroki-Heck, and S -arylation cross-coupling reactions.

In this article, we introduced a novel salen-type ligand precursor and applied it in the Pd-catalyzed Mizoroki-Heck and Cu-catalyzed S -arylation cross-coupling reactions. For the preparation of this structure, ( DL )-phenyl alanine was employed as a starting material. These ligand precursor and related catalytic system can be readily synthesised. Various aryl halides (-I, -Br) and alkenes were applied successfully in this protocol to give the corresponding Mizoroki-Heck cross-coupling and S -arylated products in high to excellent yields.