Integrated multi-omic analysis identifies fatty acid binding protein 4 as a biomarker and therapeutic target of ischemia-reperfusion injury in steatotic liver transplantation.

Mengfan YangWenzhi ShuXiangyu ZhaiXinyu YangHuaxin ZhouBinhua PanChangbiao LiDi LuJinzhen CaiShusen ZhengBin JinXuyong WeiXiao Xu

Published in: Cellular and molecular life sciences : CMLS (2024)

FABP4 was identified as a hypoxia-inducible protein that sensitized steatotic liver grafts to IR injury. The FABP4 inhibitor, BMS-309403, could activate of cAMP signaling pathway thereby modulating mitochondrial membrane homeostasis, reducing oxidative stress injury in steatotic donors.

Keyphrases

binding protein
oxidative stress
signaling pathway
fatty acid
induced apoptosis
pi k akt
endothelial cells
ischemia reperfusion injury
dna methylation
gene expression
kidney transplantation
cell proliferation
protein kinase
data analysis