High-intensity interval training induces lactylation of fatty acid synthase to inhibit lipid synthesis.

Xuefei ChenWenhua HuangJingbo ZhangYanjun LiZheng XingLanlan GuoHongfeng JiangJing Zhang

Published in: BMC biology (2023)

This investigation revealed that lactate produced by HIIT increased protein pan-lactylation levels in iWAT. FASN lactylation inhibited de novo lipogenesis, which may be an important mechanism in HIIT-induced fat loss.

Keyphrases

fatty acid
high intensity
high glucose
diabetic rats
adipose tissue
single cell
drug induced
protein protein
amino acid
metabolic syndrome
binding protein
oxidative stress
virtual reality
skeletal muscle
stress induced